Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

Phosphatidylinositol 3-kinase (PI3K) regulates many cellular functions including growth and survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through its G protein-coupled receptor (GPCR) sst2, has potent proapoptotic and anti-invasive activities on normal and canc...

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Hlavní autoři: Bousquet, Corinne, Guillermet-Guibert, Julie, Saint-Laurent, Nathalie, Archer-Lahlou, Elodie, Lopez, Frédéric, Fanjul, Marjorie, Ferrand, Audrey, Fourmy, Daniel, Pichereaux, Carole, Monsarrat, Bernard, Pradayrol, Lucien, Estève, Jean-Pierre, Susini, Christiane
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560358/
https://ncbi.nlm.nih.gov/pubmed/16917505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601279
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