Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation

The G protein-coupled sst2 somatostatin receptor acts as a negative cell growth regulator. Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase SHP-1. We now identified Src and SHP-2 as sst2-associated molecules and demonstrated their role in sst2 signaling. S...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ferjoux, Geraldine, Lopez, Frederic, Esteve, Jean-Pierre, Ferrand, Audrey, Vivier, Eric, Vely, Frederic, Saint-Laurent, Nathalie, Pradayrol, Lucien, Buscail, Louis, Susini, Christiane
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2003
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC196590/
https://ncbi.nlm.nih.gov/pubmed/12972574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-02-0069
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky