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Evidence Providing New Insights into TOB-Promoted Deadenylation and Supporting a Link between TOB's Deadenylation-Enhancing and Antiproliferative Activities

The mammalian TOB1 and TOB2 proteins have emerged as key players in repressing cell proliferation. Accumulating evidence indicates that TOBs regulate mRNA deadenylation. A recruitment model was proposed in which TOBs promote deadenylation by recruiting CAF1-CCR4 deadenylase complex to the 3′ end of...

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מידע ביבליוגרפי
Main Authors: Ezzeddine, Nader, Chen, Chyi-Ying A., Shyu, Ann-Bin
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295015/
https://ncbi.nlm.nih.gov/pubmed/22252318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06370-11
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