Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway

Alzheimer’s disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stre...

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Bibliografiske detaljer
Main Authors: Huang, Xiumei, Chen, Yaomin, Zhang, Han, Ma, Qilin, Zhang, Yun-wu, Xu, Huaxi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294262/
https://ncbi.nlm.nih.gov/pubmed/22056200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.10.007
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