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Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

One mechanism leading to neurodegeneration during Alzheimer’s disease (AD) is amyloid β peptide (Aβ) neurotoxicity. Aβ elicits in cultured central nervous system neurons a biphasic response: a low-dose neurotrophic response and a high-dose neurotoxic response. Previously we reported that NF-κB is ac...

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Detalhes bibliográficos
Main Authors: Kaltschmidt, Barbara, Uherek, Martin, Wellmann, Henning, Volk, Benedikt, Kaltschmidt, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17796/
https://ncbi.nlm.nih.gov/pubmed/10430956
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