Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Amyloid β peptide (Aβ)-containing plaques are a hallmark of Alzheimer disease. Here, we show that the neurotoxic Aβ, a major plaque component, is a potent activator of the transcription factor NF-κB in primary neurons. This activation required reactive oxygen intermediates as messengers because an a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaltschmidt, Barbara, Uherek, Martin, Volk, Benedikt, Baeuerle, Patrick A., Kaltschmidt, Christian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20142/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2642
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