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Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Amyloid β peptide (Aβ)-containing plaques are a hallmark of Alzheimer disease. Here, we show that the neurotoxic Aβ, a major plaque component, is a potent activator of the transcription factor NF-κB in primary neurons. This activation required reactive oxygen intermediates as messengers because an a...

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Main Authors: Kaltschmidt, Barbara, Uherek, Martin, Volk, Benedikt, Baeuerle, Patrick A., Kaltschmidt, Christian
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences of the USA 1997
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC20142/
https://ncbi.nlm.nih.gov/pubmed/9122249
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