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Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
Amyloid β peptide (Aβ)-containing plaques are a hallmark of Alzheimer disease. Here, we show that the neurotoxic Aβ, a major plaque component, is a potent activator of the transcription factor NF-κB in primary neurons. This activation required reactive oxygen intermediates as messengers because an a...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The National Academy of Sciences of the USA
1997
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20142/ https://ncbi.nlm.nih.gov/pubmed/9122249 |
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