DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory

DNA methylation is commonly thought of as a "molecular lock" that leads to permanent gene silencing. To investigate this notion, we tested 24 different HDAC inhibitors (HDACi) on colon cancer cells that harbor a GFP locus stably integrated and silenced by a hypermethylated CMV promoter. We...

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Библиографические подробности
Главные авторы: Raynal, Noël J.-M., Si, Jiali, Taby, Rodolphe F., Gharibyan, Vazganush, Ahmed, Saira, Jelinek, Jaroslav, Estécio, Marcos R.H., Issa, Jean-Pierre J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294136/
https://ncbi.nlm.nih.gov/pubmed/22219169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3248
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