LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability

BACKGROUND: Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently. This study was performed to determine the relationship between DNA hypomethyl...

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Detalhes bibliográficos
Main Authors: Estécio, Marcos R.H., Gharibyan, Vazganush, Shen, Lanlan, Ibrahim, Ashraf E.K., Doshi, Ketan, He, Rong, Jelinek, Jaroslav, Yang, Allen S., Yan, Pearlly S., Huang, Tim H-M., Tajara, Eloiza H., Issa, Jean-Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851990/
https://ncbi.nlm.nih.gov/pubmed/17476321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000399
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