Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin

Sickle cell anemia is characterized by chronic hemolysis coupled with extensive vascular inflammation. This inflammatory state also mechanistically promotes a high risk of lethal, invasive pneumococcal infection. Current treatments to reduce vaso-occlusive complications include chronic hydroxyurea t...

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Main Authors: Lebensburger, Jeffrey D., Howard, Thad, Hu, Yunming, Pestina, Tamara I., Gao, Geli, Johnson, Melissa, Zakharenko, Stanislav S., Ware, Russell E., Tuomanen, Elaine I., Persons, Derek A., Rosch, Jason W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293645/
https://ncbi.nlm.nih.gov/pubmed/22130804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-374447
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