Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress, reflected by elevated oxygen extraction fraction (OEF), which likely drives stroke risk reduction. The region of highest OEF...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Fields, Melanie E., Guilliams, Kristin P., Ragan, Dustin, Binkley, Michael M., Mirro, Amy, Fellah, Slim, Hulbert, Monica L., Blinder, Morey, Eldeniz, Cihat, Vo, Katie, Shimony, Joshua S., Chen, Yasheng, McKinstry, Robert C., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543515/
https://ncbi.nlm.nih.gov/pubmed/30858231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-876318
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