Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress, reflected by elevated oxygen extraction fraction (OEF), which likely drives stroke risk reduction. The region of highest OEF...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Fields, Melanie E., Guilliams, Kristin P., Ragan, Dustin, Binkley, Michael M., Mirro, Amy, Fellah, Slim, Hulbert, Monica L., Blinder, Morey, Eldeniz, Cihat, Vo, Katie, Shimony, Joshua S., Chen, Yasheng, McKinstry, Robert C., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543515/
https://ncbi.nlm.nih.gov/pubmed/30858231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-876318
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