Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia

Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia (SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and oxygen extraction fraction (OEF) are elevated in SCA, likely compensating for reduced arterial oxygen content (CaO(2))....

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Guilliams, Kristin P., Fields, Melanie E., Ragan, Dustin K., Eldeniz, Cihat, Binkley, Michael M., Chen, Yasheng, Comiskey, Liam S., Doctor, Allan, Hulbert, Monica L., Shimony, Joshua S., Vo, Katie D., McKinstry, Robert C., An, Hongyu, Lee, Jin-Moo, Ford, Andria L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833262/
https://ncbi.nlm.nih.gov/pubmed/29255068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-06-789842
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