Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease

OBJECTIVE: To determine mechanisms underlying regional vulnerability to infarction in sickle cell disease (SCD) by measuring voxel-wise cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen utilization (CMRO(2)) in children with SCD. METHODS: Participants...

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Pubblicato in:Neurology
Autori principali: Fields, Melanie E., Guilliams, Kristin P., Ragan, Dustin K., Binkley, Michael M., Eldeniz, Cihat, Chen, Yasheng, Hulbert, Monica L., McKinstry, Robert C., Shimony, Joshua S., Vo, Katie D., Doctor, Allan, An, Hongyu, Ford, Andria L., Lee, Jin-Moo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880632/
https://ncbi.nlm.nih.gov/pubmed/29500287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000005194
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