Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

Sickle cell disease (SCD) is characterized by intravascular hemolysis and inflammation coupled to a 400-fold greater incidence of invasive pneumococcal infection resulting in fulminant, lethal pneumococcal sepsis. Mechanistically, invasive infection is facilitated by a proinflammatory state that enh...

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Main Authors: Rosch, Jason W., Boyd, Angela R., Hinojosa, Ernesto, Pestina, Tamara, Hu, Yunming, Persons, Derek A., Orihuela, Carlos J., Tuomanen, Elaine I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810080/
https://ncbi.nlm.nih.gov/pubmed/20093777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39843
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