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Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease
Sickle cell disease (SCD) is characterized by intravascular hemolysis and inflammation coupled to a 400-fold greater incidence of invasive pneumococcal infection resulting in fulminant, lethal pneumococcal sepsis. Mechanistically, invasive infection is facilitated by a proinflammatory state that enh...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810080/ https://ncbi.nlm.nih.gov/pubmed/20093777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39843 |
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