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Age-associated inflammation and Toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia

BACKGROUND: Aging is associated with increased inflammation and risk for community-acquired pneumonia (CAP). Streptococcus pneumoniae co-opts the NFkB-regulated proteins Polymeric immunoglobulin receptor (pIgR) and Platelet-activating factor receptor (PAFr) to attach and invade cells. We sought to d...

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Bibliografiske detaljer
Main Authors: Hinojosa, Ernesto, Boyd, Angela R., Orihuela, Carlos J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102250/
https://ncbi.nlm.nih.gov/pubmed/19586419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/600870
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