Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin

Increased levels of red cell fetal hemogloblin, whether due to hereditary persistence of expression or from induction with hydroxyurea therapy, effectively ameliorate sickle cell disease (SCD). Therefore, we developed erythroid-specific, γ-globin lentiviral vectors for hematopoietic stem cell (HSC)-...

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Main Authors: Pestina, Tamara I, Hargrove, Phillip W, Jay, Dennis, Gray, John T, Boyd, Kelli M, Persons, Derek A
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670570/
https://ncbi.nlm.nih.gov/pubmed/19050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.259
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