Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin

Increased levels of red cell fetal hemogloblin, whether due to hereditary persistence of expression or from induction with hydroxyurea therapy, effectively ameliorate sickle cell disease (SCD). Therefore, we developed erythroid-specific, γ-globin lentiviral vectors for hematopoietic stem cell (HSC)-...

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Autors principals: Pestina, Tamara I, Hargrove, Phillip W, Jay, Dennis, Gray, John T, Boyd, Kelli M, Persons, Derek A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670570/
https://ncbi.nlm.nih.gov/pubmed/19050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.259
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