Загрузка...

The C-terminal Proteolytic Fragment of the Breast Cancer Susceptibility Type 1 Protein (BRCA1) Is Degraded by the N-end Rule Pathway

The breast cancer susceptibility type 1 gene product (BRCA1) is cleaved by caspases upon the activation of apoptotic pathways. After proteolysis the C-terminal fragment has been reported to translocate to the cytoplasm and promote cell death. Here we report that the C-terminal fragment is unstable i...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Xu, Zhizhong, Payoe, Roshani, Fahlman, Richard P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293596/
https://ncbi.nlm.nih.gov/pubmed/22262859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301002
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!