Carregant...

The C-terminal Proteolytic Fragment of the Breast Cancer Susceptibility Type 1 Protein (BRCA1) Is Degraded by the N-end Rule Pathway

The breast cancer susceptibility type 1 gene product (BRCA1) is cleaved by caspases upon the activation of apoptotic pathways. After proteolysis the C-terminal fragment has been reported to translocate to the cytoplasm and promote cell death. Here we report that the C-terminal fragment is unstable i...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Xu, Zhizhong, Payoe, Roshani, Fahlman, Richard P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293596/
https://ncbi.nlm.nih.gov/pubmed/22262859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301002
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!