Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

Mammalian cells maintain iron homeostasis by sensing changes in bioavailable iron levels and promoting adaptive responses. FBXL5 is a subunit of an E3 ubiquitin ligase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptional regulator of several genes involv...

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Detalhes bibliográficos
Main Authors: Thompson, Joel W., Salahudeen, Ameen A., Chollangi, Srinivas, Ruiz, Julio C., Brautigam, Chad A., Makris, Thomas M., Lipscomb, John D., Tomchick, Diana R., Bruick, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293540/
https://ncbi.nlm.nih.gov/pubmed/22253436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308684
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