Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ibα Strengthens Ligand Interaction

Leucine-rich repeat (LRR) is a versatile motif widely present in adhesive proteins and signal-transducing receptors. The concave structure formed by a group of LRRs is thought to facilitate binding to globular protein domains with increased affinities. However, little is known about the conformation...

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Bibliographic Details
Published in:Biophys J
Main Authors: Ju, Lining, Lou, Jizhong, Chen, Yunfeng, Li, Zhenhai, Zhu, Cheng
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Biophysical Letter
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643204/
https://ncbi.nlm.nih.gov/pubmed/26536255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.050
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