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Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

How cells sense their mechanical environment and transduce forces into biochemical signals is a crucial yet unresolved question in mechanobiology. Platelets use receptor glycoprotein Ib (GPIb), specifically its α subunit (GPIbα), to signal as they tether and translocate on von Willebrand factor (VWF...

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Vydáno v:eLife
Hlavní autoři: Ju, Lining, Chen, Yunfeng, Xue, Lingzhou, Du, Xiaoping, Zhu, Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021522/
https://ncbi.nlm.nih.gov/pubmed/27434669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15447
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