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Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase
Extracellular stimulation of the B cell receptor or mast cell FcϵRI receptor activates a cascade of protein kinases, ultimately leading to antigenic or inflammation immune responses, respectively. Syk is a soluble kinase responsible for transmission of the receptor activation signal from the membran...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293529/ https://ncbi.nlm.nih.gov/pubmed/22219190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311993 |
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