FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

In response to DNA damage or replication fork stress, the Fanconi anemia (FA) pathway is activated, leading to monoubiquitination of FancD2 and FancI and their co-localization in foci. Here we show that, in the chicken DT40 cell system, multiple alanine-substitution mutations in 6 conserved and clus...

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Bibliografiske detaljer
Main Authors: Ishiai, Masamichi, Kitao, Hiroyuki, Smogorzewska, Agata, Tomida, Junya, Kinomura, Aiko, Uchida, Emi, Saberi, Alihossein, Kinoshita, Eiji, Kinoshita-Kikuta, Emiko, Koike, Tohru, Tashiro, Satoshi, Elledge, Stephen J., Takata, Minoru
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293454/
https://ncbi.nlm.nih.gov/pubmed/18931676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1504
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