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Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

New domains were progressively added to cytoplasmic aminoacyl transfer RNA (tRNA) synthetases during evolution. One example is the UNE-S domain, appended to seryl-tRNA synthetase (SerRS) in species that developed closed circulatory systems. Here we show using solution and crystal structure analyses...

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Detalhes bibliográficos
Main Authors: Xu, Xiaoling, Shi, Yi, Zhang, Hui-Min, Swindell, Eric C., Marshall, Alan G., Guo, Min, Kishi, Shuji, Yang, Xiang-Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293412/
https://ncbi.nlm.nih.gov/pubmed/22353712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1686
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