Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease

Aims: Mitochondrial damage due to Ca(2+) overload-induced opening of permeability transition pores (PTP) is believed to play a role in selective degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). Genetic ablation of mitochondrial matrix protein cyclophilin D (CYPD)...

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Main Authors: Thomas, Bobby, Banerjee, Rebecca, Starkova, Natalia N., Zhang, Steven F., Calingasan, Noel Y., Yang, Lichuan, Wille, Elizabeth, Lorenzo, Beverly J., Ho, Daniel J., Beal, M. Flint, Starkov, Anatoly
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Forum Original Research CommunicationTargeting Mitochondria in Parkinson's (B. Thomas, Ed.)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292750/
https://ncbi.nlm.nih.gov/pubmed/21529244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3849
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