Binding of CD40L to Mac-1’s I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis – but does not affect immunity and thrombosis in mice

RATIONALE: CD40L figures prominently in chronic inflammatory diseases such as atherosclerosis. However, since CD40L potently regulates immune function and haemostasis by interaction with CD40 receptor and the platelet integrin GPIIb/IIIa, its global inhibition compromises host defense and generated...

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Main Authors: Wolf, Dennis, Hohmann, Jan-David, Wiedemann, Ansgar, Bledzka, Kamila, Blankenbach, Hermann, Marchini, Timoteo, Gutte, Katharina, Zeschky, Katharina, Bassler, Nicole, Hoppe, Natalie, Rodriguez, Alexandra Ortiz, Herr, Nadine, Hilgendorf, Ingo, Stachon, Peter, Willecke, Florian, Dürschmied, Daniel, von zur Mühlen, Constantin, Soloviev, Dmitry A., Zhang, Li, Bode, Christoph, Plow, Edward F., Libby, Peter, Peter, Karlheinz, Zirlik, Andreas
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291815/
https://ncbi.nlm.nih.gov/pubmed/21998326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.247684
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