A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel m...

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Pubblicato in:Nat Commun
Autori principali: Wolf, Dennis, Anto-Michel, Nathaly, Blankenbach, Hermann, Wiedemann, Ansgar, Buscher, Konrad, Hohmann, Jan David, Lim, Bock, Bäuml, Marina, Marki, Alex, Mauler, Maximilian, Duerschmied, Daniel, Fan, Zhichao, Winkels, Holger, Sidler, Daniel, Diehl, Philipp, Zajonc, Dirk M, Hilgendorf, Ingo, Stachon, Peter, Marchini, Timoteo, Willecke, Florian, Schell, Maximilian, Sommer, Björn, von zur Muhlen, Constantin, Reinöhl, Jochen, Gerhardt, Teresa, Plow, Edward F., Yakubenko, Valentin, Libby, Peter, Bode, Christoph, Ley, Klaus, Peter, Karlheinz, Zirlik, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802769/
https://ncbi.nlm.nih.gov/pubmed/29410422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02896-8
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