Glucose lowering by SGLT2-inhibitor empagliflozin accelerates atherosclerosis regression in hyperglycemic STZ-diabetic mice

Diabetes worsens atherosclerosis progression and leads to a defect in repair of arteries after cholesterol reduction, a process termed regression. Empagliflozin reduces blood glucose levels via inhibition of the sodium glucose cotransporter 2 (SGLT-2) in the kidney and has been shown to lead to a ma...

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Pubblicato in:Sci Rep
Autori principali: Pennig, Jan, Scherrer, Philipp, Gissler, Mark Colin, Anto-Michel, Nathaly, Hoppe, Natalie, Füner, Lisa, Härdtner, Carmen, Stachon, Peter, Wolf, Dennis, Hilgendorf, Ingo, Mullick, Adam, Bode, Christoph, Zirlik, Andreas, Goldberg, Ira J., Willecke, Florian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884628/
https://ncbi.nlm.nih.gov/pubmed/31784656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54224-9
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