Binding of CD40L to Mac-1’s I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis – but does not affect immunity and thrombosis in mice

RATIONALE: CD40L figures prominently in chronic inflammatory diseases such as atherosclerosis. However, since CD40L potently regulates immune function and haemostasis by interaction with CD40 receptor and the platelet integrin GPIIb/IIIa, its global inhibition compromises host defense and generated...

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Hauptverfasser: Wolf, Dennis, Hohmann, Jan-David, Wiedemann, Ansgar, Bledzka, Kamila, Blankenbach, Hermann, Marchini, Timoteo, Gutte, Katharina, Zeschky, Katharina, Bassler, Nicole, Hoppe, Natalie, Rodriguez, Alexandra Ortiz, Herr, Nadine, Hilgendorf, Ingo, Stachon, Peter, Willecke, Florian, Dürschmied, Daniel, von zur Mühlen, Constantin, Soloviev, Dmitry A., Zhang, Li, Bode, Christoph, Plow, Edward F., Libby, Peter, Peter, Karlheinz, Zirlik, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291815/
https://ncbi.nlm.nih.gov/pubmed/21998326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.247684
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