Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic bronchitis (CB). While many of these responses are determined genetically, little is known about the effects CS can exert on pulmonary epithelia at the protein level. We, therefore, tested the hypothesis that CS e...

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Hlavní autoři: Clunes, Lucy A., Davies, Catrin M., Coakley, Raymond D., Aleksandrov, Andrei A., Henderson, Ashley G., Zeman, Kirby L., Worthington, Erin N., Gentzsch, Martina, Kreda, Silvia M., Cholon, Deborah, Bennett, William D., Riordan, John R., Boucher, Richard C., Tarran, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2012
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290447/
https://ncbi.nlm.nih.gov/pubmed/21990373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-192377
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