Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic bronchitis (CB). While many of these responses are determined genetically, little is known about the effects CS can exert on pulmonary epithelia at the protein level. We, therefore, tested the hypothesis that CS e...

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Hauptverfasser: Clunes, Lucy A., Davies, Catrin M., Coakley, Raymond D., Aleksandrov, Andrei A., Henderson, Ashley G., Zeman, Kirby L., Worthington, Erin N., Gentzsch, Martina, Kreda, Silvia M., Cholon, Deborah, Bennett, William D., Riordan, John R., Boucher, Richard C., Tarran, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2012
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290447/
https://ncbi.nlm.nih.gov/pubmed/21990373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-192377
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