Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

Here we demonstrate a new paradigm in redox signaling, whereby oxidants resulting from metabolic stress directly alter protein palmitoylation by oxidizing reactive cysteine thiolates. In mice fed a high-fat, high-sucrose diet and in cultured endothelial cells (ECs) treated with high palmitate and hi...

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Detalhes bibliográficos
Main Authors: Burgoyne, Joseph R., Haeussler, Dagmar J., Kumar, Vikas, Ji, Yuhan, Pimental, David R., Zee, Rebecca S., Costello, Cathrine E., Lin, Cheng, McComb, Mark E., Cohen, Richard A., Bachschmid, Markus M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290434/
https://ncbi.nlm.nih.gov/pubmed/22085642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-189415
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