Endomembrane H-Ras Controls Vascular Endothelial Growth Factor-induced Nitric-oxide Synthase-mediated Endothelial Cell Migration

We demonstrate for the first time that endomembrane-delimited H-Ras mediates VEGF-induced activation of endothelial nitric-oxide synthase (eNOS) and migratory response of human endothelial cells. Using thiol labeling strategies and immunofluorescent cell staining, we found that only 31% of total H-R...

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Detalhes bibliográficos
Main Authors: Haeussler, Dagmar J., Pimentel, David R., Hou, Xiuyun, Burgoyne, Joseph R., Cohen, Richard A., Bachschmid, Markus M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663556/
https://ncbi.nlm.nih.gov/pubmed/23548900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427765
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