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The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Chemokines exert their function by binding the GPCR class of receptors on leukocytes and cell surface GAGs in target tissues. Most chemokines reversibly exist as monomers and dimers, but very little is known regarding the molecular mechanisms by which the monomer-dimer equilibrium modulates in vivo...

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Библиографические подробности
Главные авторы: Gangavarapu, Pavani, Rajagopalan, Lavanya, Kolli, Deepthi, Guerrero-Plata, Antonieta, Garofalo, Roberto P., Rajarathnam, Krishna
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Leukocyte Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290428/
https://ncbi.nlm.nih.gov/pubmed/22140266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0511239
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