Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection.

Efforts have been made to improve the biological stability of phosphodiester (PO) oligonucleotides by the addition of various modifications to either the 3', 5' or both the 3' and 5' ends of an oligonucleotide. ISIS 1080, a phosphorothioate (PS) 21-mer oligonucleotide complementa...

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Detalhes bibliográficos
Main Authors: Hoke, G D, Draper, K, Freier, S M, Gonzalez, C, Driver, V B, Zounes, M C, Ecker, D J
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC328985/
https://ncbi.nlm.nih.gov/pubmed/1658742
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