Antisense phosphorothioate oligonucleotides: selective killing of the intracellular parasite Leishmania amazonensis.

We targeted the mini-exon sequence, present at the 5' end of every mRNA of the protozoan parasite Leishmania amazonensis, by phosphorothioate oligonucleotides. A complementary 16-mer (16PS) was able to kill amastigotes--the intracellular stage of the parasite--in murine macrophages in culture. After...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ramazeilles, C, Mishra, R K, Moreau, S, Pascolo, E, Toulmé, J J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44503/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8058724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.17.7859
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