Antisense phosphorothioate oligonucleotides: selective killing of the intracellular parasite Leishmania amazonensis.

We targeted the mini-exon sequence, present at the 5' end of every mRNA of the protozoan parasite Leishmania amazonensis, by phosphorothioate oligonucleotides. A complementary 16-mer (16PS) was able to kill amastigotes--the intracellular stage of the parasite--in murine macrophages in culture....

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Bibliografiska uppgifter
Huvudupphovsmän: Ramazeilles, C, Mishra, R K, Moreau, S, Pascolo, E, Toulmé, J J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1994
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC44503/
https://ncbi.nlm.nih.gov/pubmed/8058724
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