In vitro toxicological evaluation of ISIS 1082, a phosphorothioate oligonucleotide inhibitor of herpes simplex virus.

ISIS 1082, a phosphorothioate oligonucleotide targeted to a translation initiation codon of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) virion capsid protein UL13 inhibits in vitro viral replication. To better understand the pharmacological properties of ISIS 1082, we...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Crooke, R M, Hoke, G D, Shoemaker, J E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1377898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.3.527
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