Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Single-stranded antisense oligonucleotides (SSOs) are used to modulate the expression of genes in animal models and are being investigated as potential therapeutics. To better understand why synthetic SSOs accumulate in the same intracellular location as the target RNA, we have isolated a novel mous...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Koller, Erich, Vincent, Thomas M., Chappell, Alfred, De, Soma, Manoharan, Muthiah, Bennett, C. Frank
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2011
נושאים:
Molecular Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://ncbi.nlm.nih.gov/pubmed/21345934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr089
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים