Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Single-stranded antisense oligonucleotides (SSOs) are used to modulate the expression of genes in animal models and are being investigated as potential therapeutics. To better understand why synthetic SSOs accumulate in the same intracellular location as the target RNA, we have isolated a novel mous...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koller, Erich, Vincent, Thomas M., Chappell, Alfred, De, Soma, Manoharan, Muthiah, Bennett, C. Frank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2011
Pynciau:
Molecular Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://ncbi.nlm.nih.gov/pubmed/21345934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr089
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg