Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Single-stranded antisense oligonucleotides (SSOs) are used to modulate the expression of genes in animal models and are being investigated as potential therapeutics. To better understand why synthetic SSOs accumulate in the same intracellular location as the target RNA, we have isolated a novel mous...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Koller, Erich, Vincent, Thomas M., Chappell, Alfred, De, Soma, Manoharan, Muthiah, Bennett, C. Frank
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://ncbi.nlm.nih.gov/pubmed/21345934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr089
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki