Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Single-stranded antisense oligonucleotides (SSOs) are used to modulate the expression of genes in animal models and are being investigated as potential therapeutics. To better understand why synthetic SSOs accumulate in the same intracellular location as the target RNA, we have isolated a novel mous...

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Main Authors: Koller, Erich, Vincent, Thomas M., Chappell, Alfred, De, Soma, Manoharan, Muthiah, Bennett, C. Frank
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
主題:
Molecular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://ncbi.nlm.nih.gov/pubmed/21345934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr089
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