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O6-methylguanine inhibits the binding of transcription factors to DNA.

To study the effect of methylation of O6-guanine on the binding of cellular factors to different DNA sequences, modified oligonucleotides were constructed, in which O6-Methylguanine (O6-MeG) replaced some guanines. The DNA sequences utilized were: the region of the c-fos promoter containing the bind...

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Bibliographic Details
Main Authors: Bonfanti, M, Broggini, M, Prontera, C, D'Incalci, M
Format: Artigo
Language:Inglês
Published: 1991
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC328984/
https://ncbi.nlm.nih.gov/pubmed/1945851
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