Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination

We previously reported that the combinatorial use of T20 and T1144, the first and next generations of HIV fusion inhibitors, containing different functional domains resulted in synergistic anti-HIV-1 effect, but this effect diminished when T20 and T1144 were covalently linked together. To elucidate...

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Autores principales: Cai, Lifeng, Pan, Chungen, Xu, Liang, Shui, Yuan, Liu, Keliang, Jiang, Shibo
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289504/
https://ncbi.nlm.nih.gov/pubmed/22085645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-195289
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