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A Novel Chimeric Protein-based HIV-1 Fusion Inhibitor Targeting gp41 Glycoprotein with High Potency and Stability

T20 (enfuvirtide, Fuzeon) is the first generation HIV-1 fusion inhibitor approved for salvage therapy of HIV-1-infected patients refractory to current antiretroviral drugs. However, its application is limited by the high cost of peptide synthesis, rapid proteolysis, and poor efficacy against emergin...

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Главные авторы: Pan, Chungen, Cai, Lifeng, Lu, Hong, Lu, Lu, Jiang, Shibo
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151085/
https://ncbi.nlm.nih.gov/pubmed/21690094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241992
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