Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination

We previously reported that the combinatorial use of T20 and T1144, the first and next generations of HIV fusion inhibitors, containing different functional domains resulted in synergistic anti-HIV-1 effect, but this effect diminished when T20 and T1144 were covalently linked together. To elucidate...

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Detalhes bibliográficos
Main Authors: Cai, Lifeng, Pan, Chungen, Xu, Liang, Shui, Yuan, Liu, Keliang, Jiang, Shibo
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289504/
https://ncbi.nlm.nih.gov/pubmed/22085645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-195289
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