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Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide
Islet amyloid polypeptide (IAPP) is a peptide hormone cosecreted with insulin by pancreatic β-cells. In type II diabetes, IAPP aggregates in a process that is associated with β-cell dysfunction and loss of β-cell mass. The relationship between IAPP's conformational landscape and its capacity to...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Federation of American Societies for Experimental Biology
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289502/ https://ncbi.nlm.nih.gov/pubmed/22183778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-194613 |
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