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Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide

Islet amyloid polypeptide (IAPP) is a peptide hormone cosecreted with insulin by pancreatic β-cells. In type II diabetes, IAPP aggregates in a process that is associated with β-cell dysfunction and loss of β-cell mass. The relationship between IAPP's conformational landscape and its capacity to...

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Autors principals: Magzoub, Mazin, Miranker, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289502/
https://ncbi.nlm.nih.gov/pubmed/22183778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-194613
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