Structural reorganization of the interleukin-7 signaling complex

We report here an unliganded receptor structure in the common gamma-chain (γ(c)) family of receptors and cytokines. The crystal structure of the unliganded form of the interleukin-7 alpha receptor (IL-7Rα) extracellular domain (ECD) at 2.15 Å resolution reveals a homodimer forming an “X” geometry lo...

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Autors principals: McElroy, Craig A., Holland, Paul J., Zhao, Peng, Lim, Jae-Min, Wells, Lance, Eisenstein, Edward, Walsh, Scott T. R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289338/
https://ncbi.nlm.nih.gov/pubmed/22308406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116582109
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