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Structural and Biophysical Studies of the Human IL-7/IL-7Rα Complex

IL-7 and IL-7Rα bind the γ(c) receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report the IL-7Rα ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the γ(c) family. IL-...

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Autori principali: McElroy, Craig A., Dohm, Julie A., Walsh, Scott T. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654238/
https://ncbi.nlm.nih.gov/pubmed/19141282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.019
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