Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 recepto...

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Main Authors: Lundström, Wangko, Highfill, Steven, Walsh, Scott T. R., Beq, Stephanie, Morse, Elizabeth, Kockum, Ingrid, Alfredsson, Lars, Olsson, Tomas, Hillert, Jan, Mackall, Crystal L.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651437/
https://ncbi.nlm.nih.gov/pubmed/23610432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222303110
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