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Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 recepto...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651437/ https://ncbi.nlm.nih.gov/pubmed/23610432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222303110 |
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