Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 recepto...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lundström, Wangko, Highfill, Steven, Walsh, Scott T. R., Beq, Stephanie, Morse, Elizabeth, Kockum, Ingrid, Alfredsson, Lars, Olsson, Tomas, Hillert, Jan, Mackall, Crystal L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651437/
https://ncbi.nlm.nih.gov/pubmed/23610432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222303110
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky