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Structural and Biophysical Studies of the Human IL-7/IL-7Rα Complex
IL-7 and IL-7Rα bind the γ(c) receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report the IL-7Rα ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the γ(c) family. IL-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654238/ https://ncbi.nlm.nih.gov/pubmed/19141282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.019 |
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